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The long term and well documented experience of the DI.V.A.L.’s team in oncological research as well as in ion-channels-related studies has led them to have a great expertise in analyzing pharmacological compounds, developing oncological models and producing and manipulating antibodies for research purposes.

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Annarosa Arcangeli

 

MD, Specialist in Hematology, PhD in Experimental Pathology and Professor of General Pathology. Dr. Arcangeli has conducted several researches on ionic channels and their role on the neoplastic transformation. She is one of the leading expert on hERG channels and their role in neuronal and cancer cells. Working at the University of Cambridge, Prof. Arcangeli has gathered experience in the production of genetically modified animals. Moreover Dr. Arcangeli is an expert in producing, humanizing and nanizing monoclonal antibodies through recombinant DNA methods.

From 2006 she is the scientific director of  L.I.Ge.M.A. (Laboratory of Genetic Engineering for the production of animal models).

She is the Scientific Director and Project Manager Responsible.

 

***Peer reviewed publications*** 

1) Olivotto, M., Boddi, V., Dello Sbarba, P. and Arcangeli, A., A comparative kinetic analysis of proliferation in vitro of ConA treated splenocytes and syngenic leukaemia cells. Cell and tissue kinetics, 15,623-636,1982. IF: 1.529

2) Olivotto, M., Arcangeli, A., Caldini, R., Chevanne, M., Cipolleschi M.G. and  Dello Sbarba P., Metabolic aspects of cell cycle regulation in normal and cancer cells. Toxicologic Pathology, 12, 369- 373,1984. IF:1.230

3) Arcangeli, A and Olivotto, M., Plasma membrane potential of murine erythroleukemia cells: approach to measurement and evidence for  cell density dependence. J. Cell. Physiol., 127, 17-27,1986. IF: 5.463

4) Bernabei, P.A., Arcangeli, A., Casini, M., Grossi, A., Padovani, R. and Rossi Ferrini, P., Platelet-derived growth factor(s) mitogenic activity in patients with myeloproliferative disease. British J. Haematol., 63, 353-357, 1986. IF:3.267

5) Arcangeli, A., Ricupero, L. and Olivotto, M., Commitment to differentiation of murine erythroleukemia cells involves a modulated plasma membrane depolarization through Ca2+-activated K+ channels.  J. Cell. Physiol., 132,387-400, 1987. IF:5.463

6) Arcangeli, A., Wanke, E., Olivotto, M., Camagni ,S. and Ferroni, A., Three types of ion channels are present on the plasma membrane of Friend erythroleukemia cells. Biochem. Biophys. Res. Commun., 146, 1450-1457, 1987. IF:2.836

7) Fallani,A., Arcangeli,A., Ruggieri,S., Lipid changes associated with erythroid differentiation of Friend erythroleukemia cells. Toxicologic Pathology,15,170-177,1987. IF:1.230

8) Fallani, A., Arcangeli, A. and Ruggieri, S., Lipid characteristics of Friend erythroleukaemia cells differentiated by dimethyl sulphoxide or hexamethylenebisacetamide, and of non-inducible clones treated with the inducers. Biochem. J., 252, 917-920, 1988. IF:4.101

9) Fallani, A., Arcangeli, A. and Ruggieri, S., Characteristics of ether-linked glycerophospholipids in Friend erythroleukaemia cells differentiated by dimethyl sulphoxide or hexamethylenebisacetamide and in non-inducible clones treated with the inducers. Biochem. J., 255, 731-736, 1988. IF:4.101

10) Arcangeli, A., Del Bene, M.R., Ricupero, L., Ballerini, L. and Olivotto, M., Fibronectin hyperpolarizes the plasma membrane potential of murine erythroleukemia cells. Ann. N.Y. Acad. Sci., 551, 242- 244, 1988. IF:1.892

11) Arcangeli, A., Del Bene, M.R., Poli, R., Ricupero, L. and Olivotto, M., Mutual contact of murine erythroleukemia cells activates depolarizing cation channels, whereas contact with extracellular substrata activates depolarizing Ca 2+ -dependent K+ channels.  J. Cell. Physiol.,139,1-8,1989. IF 5.463

12) Arcangeli, A., Becchetti, A., Del Bene, M.R., Wanke, E. and Olivotto, M., Fibronectin-integrin binding promotes hyperpolarization of Murine Erythroleukemia cells. Biochem.Biophys.Res.Commun., 177, 1266-1272, 1991. IF:2.836

13) Arcangeli, A., Del Bene, M.R., Becchetti, A., Wanke, E. and Olivotto, M., Effects of inhibitors of ion motive ATPases on the plasma membrane potential of murine erythroleukemia cells. J. Membr.Biol., 126, 123-136, 1992. IF:2.203

14) Becchetti, A., Arcangeli, A., Del Bene, M.R., Olivotto, M. and Wanke, E. Response to Fibronectin-integrin interaction in leukaemia cells : delayed enhancing of a K+ current. Proc. Royal Soc. Ser.B, 248, 235-240, 1992 . IF:1.210

15) Becchetti,A., Arcangeli,A., Del Bene, M.R., Olivotto,M. and Wanke,E. Intra and extracellular surface charges near Ca2+ channels in neuroblastoma cells.  channels in neurons and neuroblastoma cells Biophys.J., 63,954-965,1992. IF:4.463

16) Arcangeli, A., Carla', M., Del Bene, M.R., Becchetti, A., Wanke, E. and Olivotto, M. Polar/apolar compounds induce leukemia cell differentiation by modulating cell- surface potential. Proc. Natl.Acad. Sci. USA, 90, 5858-5862,1993. IF:10.272

17) Arcangeli, A., Becchetti, A., Mannini, A., Mugnai, G., Tarone, G., Defilippi, P., Del Bene, M.R., Barletta, E.,Wanke, E. and Olivotto, M. Integrin-mediated neurite outgrowth in Neuroblastoma cells depends on the activation of potassium channels. J.Cell Biol., 122, 1131-1143, 1993. IF:12.023

18) Carla', M., Cuomo, M., Arcangeli, A. and Olivotto, M. Adsorption properties of polar/apolar inducers at a charged interface and their relevance to leukemia cell differentiation. Biophys.J., 68,2615-2621,1995. IF:4.463

19) Bianchi, L., Arcangeli, A., Bartolini, P., Mugnai, G., Wanke, E. and Olivotto, M. An inward rectifier K+current modulates in neuroblastoma cells tyrosine phosphorylation of pp125 FAK and associated proteins: role in neuritogenesis. Biochem. Biophys. Res. Commun., 210, 823-829, 1995. IF:2.836

20) Vannelli, G. B., Ensoli, F., Zonefrati, R.,Kubota, Y.,Arcangeli, A. Becchetti A. , Camici, G. Barni, T. Thiele, C.J. and Balboni, C. Neuroblast long-term cell cultures from human fetal olfactory epithelium respond to odors. J.Neurosci.,15,4382-4394,1995. IF:8.306

21) Arcangeli, A., Bianchi, L., Becchetti, A., Faravelli, L., Coronnello, M., Mini, E., Olivotto, M. and Wanke, E. A novel inward-rectifying K+ current with a cell cycle-dependence governs the resting potential of neuroblastoma cells. J.Physiol., 489, 455-471,1995. IF:4.352

22) Olivotto, M., Arcangeli ,A., Carla' ,M. and Wanke, E. Electric fields at the plasma membrane level: a neglected element in the mechanism of cell signalling. BioEssays, 18, 495-504, 1996. IF:6.491

23) Faravelli, L., Arcangeli, A., Olivotto, M. And Wanke, E. A HERG-like K+ channel in F-11 DRG cell line: pharmacological identification and biophysical characterisation. J.Physiol., 496, 13-23, 1996. IF:4.352

24) Arcangeli,A., Faravelli, L., Bianchi, L., Rosati, B., Gritti, A. Vescovi, A., Wanke, E. and Olivotto,M. Soluble or bound Laminin elicit in human neuroblastoma cells short- or long-term potentiation of a K+ inwardly rectifying current: relevance to neuritogenesis. Cell Adhesion and Communication, 4, 369-385, 1996. IF:1.289

25) Chiesa,N., Rosati,B. Arcangeli, A.,Olivotto,M. and Wanke,E. A novel role for HERG K+ channels: spike-frequency adaptation. J.Physiol., 501, 313-318, 1997. IF:4.352

26) Arcangeli,A., Rosati, B., Cherubini, A., Crociani, O., Fontana,L., Ziller,C., Wanke, E.and Olivotto, M. HERG- and IRK-like inward rectifier currents are sequentially expressed during neuronal development of neural crest cells and their derivatives. Eur.J.Neurosci., 9, 2596-2604, 1997. IF:3.872

27) Bianchi,L., Wible,B., Arcangeli,A., Taglialatela,M., Morra,F., Castaldo,P., Crociani, O., Rosati, B., Faravelli, L., Olivotto, M. and Wanke, E. herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells? Cancer Res., 58, 815-822, 1998. IF:8.320

28) Arcangeli,A., Rosati,B., Cherubini, A., Crociani,O., Fontana,L., Passani, B., Wanke,E. and Olivotto,M. Long term exposure to Retinoic Acid induces the expression of IRK1 channels in HERG channel-endowed neuroblastoma cells. Biochem Biophys Res. Commun.,244, 706-711, 1998. IF:2.946

29) Schonherr, R., Rosati, B., Hehl, S., Rao, V.G., Arcangeli, A., Olivotto, M., Heinemann, S.H. and Wanke, E. Functional role of the slow activation gate in ERG K+ channels. Eur.J.Neurosci.,11, 753-760, 1999. IF:3.918

30) Gurrola, G.B., Rosati, B., Rocchetti,M., Pimenta, G., Zaza, A., Arcangeli,A., Olivotto,M., Possani, L.D. and Wanke,E. A toxin to nervous , cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom. FASEB J., 13, 953-962,1999. IF:8.818

31) Arcangeli,A., Rosati,B., Crociani,O., Cherubini, A., Fontana, L., Passani,B., Wanke,E. and Olivotto,M. Modulation of HERG current and herg gene expression during retinoic acid treatment of human neuroblastoma cells: potentiating effects of BDNF. J.Neurobiol.,40, 214-225, 1999. IF:3.304

32) Noci, I., Coronnello,M., Borri,P., Borrani,E., Giachi,M., Chieffi,O., Marchionni,M., Paglierani,M., Buccoliero,A.M., Cherubini,A., Arcangeli,A., Mini,E. and Taddei, G.L. Inhibitory effect of luteinising hormone-releasing hormone analogues on human endometrial cancer in vitro. Cancer Lett. 150, 71-78, 2000. IF:1.741

33) Herrero,R., Moncelli,M.R., Guidelli,R., Carla’,M., Arcengeli,A. and Olivotto,M. Hybrid polar compounds produce a positive shift in the surface dipole potential of self-assembled phospholipid monolayers. Biochim.Biophys.Acta, 1466, 278-288, 2000. IF:2.203

34) Crociani,O., Cherubini,A.,Piccini,E., Polvani,S., Costa,L., Fontana,L., Hofmann,G.,Rosati,B., Wanke,E., Olivotto,M. and Arcangeli,A. erg gene(s) expression during development of the nervos and muscular system of quail embryos. Mechanisms of Development, 95, 239-243, 2000. IF:3.687

35) Rosati,B., Marchetti,P., Crociani,O., Lecchi,M., Lupi, R., Arcangeli,A., Olivotto,M. and Wanke,E. Glucose-and arginine-induced insulin secretion by human pancreatic beta-cells : the role of HERG K+ channels in firing  and release. FASEB J., 14, 2601-2610, 2000. IF:8.818

36) Arcangeli, A., Fontana, L., Crociani, O., Cherubini, A., Hofmann,G., Piccini, E., Polvani,S., D’amico, M., Carla’, M. and Olivotto, M. A transient dephosphorylation of JAK1 and JAK2 characterizes the early- phase response of murine Erythroleukemia cells to the differentiation inducer haxamethylenbisacetamide. Leukemia, 14, 2112-2117, 2000. IF:4.693

37) Cherubini,A., Taddei,G.L., Crociani,O., Paglierani,M., Buccoliero,A.M., Fontana,L., Noci,I, Borri,P., Borrani,E., Giachi,M., Becchetti,A., Rosati,B., Wanke,E., Olivotto, M and Arcangeli, A. HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non cancerous endometrium. Br. J. Cancer, 83, 1722-1729, 2000. IF:3.942

38) Hofmann,G., Bernabei, P.A., Crociani, O., Cherubini, A., Guasti, L.*, Pillozzi, S., Lastraioli, E., Polvani, S., Bartolozzi, B., Solazzo, V., Gragnani,L., De Filippi, P., Rosati, B., Wanke, E., Olivotto, M. and Arcangeli, A. HERG K+ channels activation during b1 integrin-mediated adhesion to Fibronectin induces an up regulation of avb3 integrin in the preosteoclastic leukemia cell line FLG 29.1.J.Biol.Chem., 276, 4923-4931, 2001. IF:7.258

39) Noci,I., Borri,P., Bonfirraro,G., Chieffi,O., Arcangeli,A., Cherubini,A., Dabizzi,S., Buccoliero,Am., Paglierani,M. and Taddei, Gl. Longstanding survival without cancer progression in a patient affected by endometrial carcinoma treated primarily with leuprolide. British .J. Cancer, 85, 333-336, 2001. IF:3.942

40) Fontana, L., D’amico,M., Crociani,O., Biagiotti,T., Solazzo,M., Rosati,B., Arcangeli,A., Wanke,E. and Olivotto,M. Long-term modulation of herg channel gating in hypoxia. Biochem.Biophys.Res. Commun. 286, 857-862, 2001. IF:2.946

41) Lecchi,M., Redaelli,E., Rosati, B., Gurrola, G., Florio, T., Crociani,O., Curia, G., Restano Cussulini, R., Masi,A., Arcangeli,A., Olivotto,M., Schettini, G., Possani, L.D. and Wanke E . Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and  its accomodation role during slow firing and prolactin release. J. Neurosci., 22, 3414-3425, 2002. IF:8.178

42) Becchetti, A., De Fusco, M., Crociani, O., Cherubini, A., Restano-Cassulini, R., Lecchi, M., Arcangeli, A., Casari, G. and Wanke, E. The Human Ether-a-go-go-like (HELK2) K+ Channel:heterologous expression and properties in astrocytoma cells. Eur. J. Neurosci. 16, 415-428, 2002. IF:3.918

43) Pillozzi S., Brizzi M.F., Balzi M.,  Crociani O., Cherubini A., Guasti L., Bartolozzi B., Becchetti A., Wanke E., Bernabei P.A., Olivotto M., Pegoraro L. and Arcangeli A.HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic haemopoietic progenitors. Leukemia, 16, 1791-1798, 2002. IF:4.693

44) Cherubini A, Pillozzi S, Hofmann G, Crociani O, Guasti L, Lastraioli E, Polvani S, Masi A, Becchetti A, Wanke E, Olivotto M, and Arcangeli A. HERG K+ channels and beta1 integrins interact through the assembly of a macromolecular complex. Ann N Y Acad Sci, 973:559-61, 2002. IF:1.593

45) Gullo F, Ales E, Rosati B, Lecchi M, Masi A, Guasti L, Cano-Abad MF, Arcangeli A, Lopez MG, and Wanke E. ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? FASEB J, 17:330-2,2003. IF:7.064

46) Crociani O, Guasti L, Balzi M, Becchetti A, Wanke E, Olivotto M, Wymore RS, and Arcangeli A. Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells. J Biol Chem  278: 2947-55, 2003. IF:5.85447) D'amico M, Biagiotti T, Fontana L, Restano-Cassulini R, Lasagna N, Arcangeli A, Wanke E, and Olivotto M. A HERG current sustains a cardiac-type action potential in neuroblastoma S cells. Biochem Biophys Res Commun ,302:101-8, 2003. IF:2.648

48) Dabizzi S., Noci I., Borri P., Borrani E., Giachi M., Balzi M., Taddei G.L., Marchionni M., Scarselli G., Arcangeli A. Luteinizing hormone increase human endometrial cancer cell invasiveness through activation of PKA. Cancer Res., 63, 4281-4286, 2003. IF:7.616

49) Milnes, J.T. Dempsey, C.E., Ridley, J.M., Crociani, O., Arcangeli,A., Hancox, J.C.and Witchel,H.J. Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin. FEBS Letters, 547, 20-26, 2003 . IF:3.415

50) Milnes, J.T., Crociani,O., Arcangeli,A., Hancox,J.C., and Witchel,H.J. Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by mutation of F656 or Y652. Br.J.Pharmacol., 139, 887-898, 2003. IF:3.410

51) Polvani S., Masi A., Pillozzi S., Gragnani L., Crociani O., Wanke E., Olivotto M., and Arcangeli A.. Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1 , m-erg2 and m-erg3 . Mech. Devel. (Gene expression patterns), 3: 767-776, 2003. IF:1.794

52) Lastraioli,E., Guasti,L., Crociani,O., Polvani,S., Hofmann,G., Witchel,H., Bencini,L., Calistri,M.,  Messerini,L., Scatizzi,M., Moretti,R., Wanke,E., Olivotto,M., Mugnai,G., and Arcangeli,A. herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells. Cancer Res. 64:606-611, 2004. IF:7.617

53) Arcangeli, A., Becchetti, A., Cherubini, A., Crociani, O., Defilippi, P., Guasti, L., Hofmann, G., Pillozzi, S., Olivotto, M., & Wanke, E. Physical and functional interaction between integrins and hERG potassium channels. Biochem.Soc.Trans. 32, 826-827, 2004. IF:3.099

54) Cherubini A., Hofmann G., Pillozzi S., Guasti L., Crociani O., Cilia E, Di Stefano P., Degani S., Balzi M., Olivotto M., Wanke E., Becchetti A, Defilippi P.,Wymore R. and Arcangeli A.  Herg1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signalling. Mol. Biol. Cell. 16: 2972-2983, 2005. IF:6.520

55) Biagiotti T., D’amico M., Marzi I., Di Gennaro P., Arcangeli A., Wanke E., Olivotto M.

Cell renewing in neuroblastoma: electrophysiological and immunocytochemical characterization of stem cells and derivatives. Stem cells. 24: 443-453, 2005. IF:6.094

56) Guasti L., Cilia E., Crociani, O., Hofmann G., Polvani S., Becchetti A., Wanke E., Tempia F. and Arcangeli A. Expression Pattern Of The Ether-A-Go-Go-Related (Erg) Family Proteins In The Adult Mouse Central Nervous System: Evidence For Coassembly Of Different Subunits. J. Comp. Neurol. 491: 157-174, 2005. IF:3.855

57) Furlan F., Guasti L., Avossa D., Becchetti A., Cilia E., Ballerini L. and Arcangeli A.  Interneurons transiently express the Erg K+ channels during development of mouse spinal networks in vitro. Neurosci.135: 1179-1192, 2005. IF:3.410

58) Masi A., Becchetti A., Restano-Cassulini R., Polvani S., Hofmann G., Buccoliero A.M., Paglierani M., Pollo B., Taddei G.L., Gallina P., Di Lorenzo N., Franceschetti S., Wanke E. and Arcangeli A. hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines. Br. J. Cancer. 93: 781-792, 2005. IF:4.115

59) Salvati A., Ciani L., Ristori S., Martini G., Masi A. and  Arcangeli A. Physico-chemical characterization and transfection efficacy of cationic liposomes containing the pEGFP plasmid. Biophys. Chem. 121: 21-29, 2006. IF:1.925

60) Restano-Cassulini R., Korolkova Y.V., Diocot S., Gurrola G., Guasti L., Possani L.D., Lazdunski M., Grishin E.V., Arcangeli A. and Wanke E. Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system. Mol. Pharmacol. 69: 1673-1683, 2006. IF:4.612

61) Lastraioli E., Taddei A., Messerini L., Comin C.E., Festini M., Giannelli M., Tomezzoli A., Paglierani M., Mugnai G., De Manzoni G., Bechi P. and Arcangeli A.   hERG1 channels in human esophagus: evidence for their aberrant expression in the malignant progression of Barrett's esophagus. J. Cell. Physiol. 209: 398-404, 2006. IF:4.362

62) Arcangeli, A and Becchetti A. Complex functional interaction between integrin receptors and ion channels. Trends Cell. Biol. 16: 631-639, 2006. IF:11.791

63) Furlan F., Taccola G., Grandolfo M., Guasti L., Arcangeli A., Nistri A. and Ballerini L. ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord. J. Neurosci., 27, 919-928, 2007. IF:7.506

64) Accordi B, Pillozzi S, Campo dell’Orto M, Cazzaniga G, Arcangeli A, Te Kronnie G and Basso G. Hepatocyte gowth factor receptor c-MET is associated with FAS and when activated enhances drug-induced apoptosis in pediatric B-acute lymphoblastic leucemia with TEL-AML1 translocation. J Biol Chem. 282: 29384-29393, 2007. IF: 5.808

65) Pillozzi, S., Brizzi, M.F., Bernabei, P.A., Bartolozzi, B., Caporale, R., Basile, V., Boddi, V., Pegoraro, L., Becchetti,A., and Arcangeli, A. VEGFR-1 (FLT-1), b1 integrin and hERG K+ channel form a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome. Blood, 110: 1238-1250, 2007. IF:10.131

66) Di Costanzo F, Gasperoni S., Manzione L., Bisagni G., Labianca R., Bravi S., Cortesi E., Carlini P., Bracci R., Tomao S., Messerini L., Arcangeli A., Torri V., Bilancia D., Floriani I. and Tonato M. Adjuvant chemotherapy in completely resected gastric cancer: a randomized phase II trial conducted by GOIRC. J. Natl. Cancer Inst. 100: 1-11, 2008. IF:15.171

67) Guasti L, Crociani O, Redaelli E, Pillozzi S, Polvani S, Masselli M, Mello T, Galli A, Amedei A, Wymore RS, Wanke E and Arcangeli A. Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells. Mol Cell Biol. 28: 5043-5060, 2008 . IF: 5.942

68) Becchetti A,  Arcangeli A. A comment on ion channels as pharmacological targets in oncology.

J Gen Physiol. 132(2):313-314, 2008. IF:4.711

69) Pessia M, Servettini I, Panichi R, Guasti L, Grassi S, Arcangeli A, Wanke E, Pettorossi VE. ERG voltage-gated K+ channels regulate excitability and discharge dynamics of the medial vestibular nucleus neurons. J Physiol. 586:4877-90, 2008. IF:4.605

70) Noci I, Pillozzi S, Lastraioli E, Dabizzi S, Giachi M, Borrani E, Wimalasena J, Taddei GL, Scarselli G and Arcangeli A.  hLH/hCG-receptor expression correlates with in vitro invasiveness in human primary endometrial cancer. Gynecol Oncol.111(3):496-501, 2008. IF:2.919

71) Becchi C, Pillozzi S, Fabbri LP, Al Malyan M, Cacciapuoti C, Della Bella C, Nucera M, Masselli M, Boncinelli S, Arcangeli A, Amedei A. The increase of endothelial progenitor cells in the peripheral blood: a new parameter for detecting onset and severity of sepsis. Int J Immunopathol Pharmacol. 21(3):697-705, 2008. IF:2.793

72) Cabodi S, Morello V, Masi A, Cicchi R, Broggio C, Di Stefano P, Brunelli E, Silengo L, Pavone FS, Arcangeli A, Turco E, Tarone G, Moro L, Defilippi P. Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 transcription. J. Cell. Physiol. 218(2):294-303, 2009. IF:4.313

73) Arcangeli A, Crociani O, Lastraioli E, Masi A, Pillozzi S. and Becchetti A. Targeting ion channels in cancer: a novel frontier in antineoplastic therapy. Curr. Med. Chem. 16(1):66-93, 2009. IF:4.823

74) Redaelli E, Restano Cassulini R, Fuentes Silva D, Clement H, Schiavon E, Zamudio FZ, Odell G, Arcangeli A, Clare JJ, Alagon A, Rodriguez de la Vega RC, Possani LD, Wanke E. Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. J Biol Chem. 285: 4130-4142,2010 IF 5.5

75) Arcangeli A, Toma L, Contiero L, Crociani O, Legnani L, Lunghi C, Nesti E, Moneti G, Richichi B, Nativi C. Stable GM3 lactone mimetic raises antibodies specific for the antigens expressed on melanoma cells. Bioconjug Chem. 21(8):1432-8, 2010. IF: 5.002

76) Fortunato P, Pillozzi S, Tamburini A, Pollazzi L, Franchi A, La Torre A, Arcangeli A. Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway. BMC Cancer. 10(1):504-510, 2010. IF: 3.15

77) Pillozzi S, Masselli M,DeLorenzo E, Accordi B, Cilia E, Crociani O, Amedei A, Veltroni M, D’Amico M, Basso G, Becchetti A, Campana D and Arcangeli A. Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers. Blood 117(3):902-14, 2011. IF: 10.131

78) Laise P, Di Patti F, Fanelli D, Masselli M, Arcangeli A. Deterministic and stochastic aspects of VEGF-A production and the cooperative behavior of tumoral cell colony. J Theor Biol. 272(1):55-63, 2011. IF: 2.371

79) Arcangeli A, Yuan JX. American Journal of Physiology-Cell Physiology theme: ion channels and transporters in cancer. Am J Physiol Cell Physiol. 301 (2), C253-4. 2011. IF:3.817

80) Arcangeli A. Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk. Am J Physiol Cell Physiol. 301(4):C762-71, 2011. IF:3.817

81) Laise P., Fanelli D. and Arcangeli A. A dynamical model of apoptosis and its role in tumor progression. Communications in Nonlinear Science and Numerical Simulation 10.1016/j.cnsns.2011.09.014. IF:2.671

82) Bogani P., Spiriti M.M., Lazzarano S., Arcangeli A., Buiatti M. and Minunni M. Transgene traceability in transgenic mice: a bioanalytical approach for potential gene-doping analysis. Bioanalysis, 3(22):2523-31, 2011. IF:3.223

83) Arcangeli A., Pillozzi S. and Becchetti A. Targeting Ion Channels in Leukemias: a New Challenge for Treatment. Curr. Med. Chem.,19(5):683-9, 2012. IF: 4.823

84) Laise P., Fanelli D., Lió P. and Arcangeli A. Modeling TGF-β signaling pathway in epithelial-mesenchymal transition. AIP Advances 2, 011201, 2012. IF: 1.349

85) Lastraioli E, Bencini L, Bianchini E, Romoli MR, Crociani O, Giommoni E, Messerini L, Gasperoni S, Moretti R, Di Costanzo F, Boni L, Arcangeli A. hERG1 Channels and Glut-1 as Independent Prognostic Indicators of Worse Outcome in Stage I and II Colorectal Cancer: A Pilot Study.Transl Oncol. 5(2):105-12, 2012.IF:3.4

86) Mori M, De Lorenzo E, Torre E, Fragai M, Nativi C, Luchinat C, Arcangeli A. A Highly Soluble Matrix Metalloproteinase-9 Inhibitor for Potential Treatment of Dry Eye Syndrome. Basic Clin Pharmacol Toxicol. 111: 289-295, 2012  IF: 2.179

87) Masselli M, Laise P, Tonini G, Fanelli D, Pillozzi S, Cetica V, Da Ros M, Sardi I, Buccoliero AM, Aricò M, Genitori L, Becchetti A, Arcangeli A. Deregulation of ion channel and transporter encoding genes in pediatric gliomas. Front Ped Oncol, 2:53, 2012.

88) Lastraioli E, Romoli MR, Arcangeli A. Immunohistochemical biomarkers in gastric cancer research and management. Int J. Surg.Oncol, 2012;2012:868645.. Epub 2012 Jun 24. IF: 2.644

89) D'Amico M, Gasparoli L, Arcangeli A. Potassium Channels: Novel Emerging Biomarkers and Targets for Therapy in Cancer. Recent Pat Anticancer Drug Discov. 2012 May 8. [Epub ahead of print] IF: 2.72

90) Munaron L, Arcangeli A. Ion fluxes and Cancer. Recent Pat Anticancer Drug Discov. 2012 Jul 23. [Epub ahead of print] IF: 2.72

91) Arcangeli A, Romoli MR, Boni L, Gerlini G, Tofani L, Urso C, Borgognoni L. High hERG1 expression in advanced melanoma. Melanoma Res. 2013: 23: 185-90. IF: 2.518

 

Olivia Crociani

BSC, PhD and Researcher at Dept of Experimental Pathology and Oncology. She has an expertise in antibodies' production both polyclonal (through GST gene fusion system) and monoclonal (through the hybridoma technology). She conducted several studies  to identify specific antigen peptides for in vivo immunisation. She developed a new monoclonal antibody patented by the University of Firenze in 2006.

 

 

In DI.V.A.L., she is the responsibile of the antibody production.

Massimo DAmico

BSC, PhD and Researcher in Experimental and Clinical Oncology. Using the patch-clamp technique, he has taken part in the definition of the role of the current through the hERG potassium channels and in the regulation of the growth and differentiation of different types of tumor cells. He is able to conduct specific toxicological analysis through hERG test.

 

In DI.V.A.L., he is the responsible of specific toxicity test (hERG test).


***Peer reviewed publications***

1)Arcangeli A, Fontana L, Crociani O, Cherubini A, Hofmann G, Piccini E, Polvani S, D’Amico M, Carlà M and Olivotto M. “A transient dephosphorylation of JAK1 and JAK2 characterizes the early- phase response of murine Erythroleukemia cells to the differentiation inducer haxamethylenbisacetamide”. Leukemia 2001; 14:2112-2117.

2)Fontana L, D’Amico M, Crociani O, Biagiotti T, Solazzo M, Rosati B, Arcangeli A, Wanke E and Olivotto M. “Long-term modulation of HERG channel gating in hypoxia”. Biochem. Biophys. Res. Commun., 2001, 286, 857-862.

3)D’Amico M, Biagiotti T, Fontana L, Restano-Cassulini R, Lasagna N, Arcangeli A, Wanke E and Olivotto M. “A HERG current sustains a cardiac-type action potential in neuroblastoma S cells”. Biochem. Biophys. Res. Commun., 2003, 302, 101-108.

4)Sacconi L, D'Amico M, Vanzi F, Biagiotti T, Antolini R, Olivotto M, Pavone FS. “Second-harmonic generation sensitivity to transmembrane potential in normal and tumor cells. J Biomed Opt. 2005, 10, 024014.

5)Biagiotti T, D'Amico M, Marzi I, Di Gennaro P, Arcangeli A, Wanke E, Olivotto M. “Cell renewing in neuroblastoma: electrophysiological and immunocytochemical characterization of stem cells and derivatives”. Stem Cells. 2006, 24(2), 443-53.

6)Sacconi L, Tolic-Norrelykke IM, D'Amico M, Vanzi F, Olivotto M, Antolini R, Pavone“Cell imaging and manipulation by nonlinear optical microscopy”. Cell Biochem Biophys. 2006;45(3):289-302.

7)Marzi I, D'Amico M, Biagiotti T, Giunti S, Carbone MV, Fredducci D, Wanke E, Olivotto M. “Purging of the neuroblastoma stem cell compartment and tumor regression on exposure to hypoxia or cytotoxic treatment”. Cancer Res. 2007 Mar 15;67(6):2402-7 

8)Becucci L, Carbone MV, Biagiotti T, D'Amico M, Olivotto M, Guidelli R. “Incorporation ofHERG potassium channel in a mercury supported lipid bilayer”. J Phys Chem B. 2008 Jan 31;112(4):1315-9.     

9)Solazzo M, Fantappiè O, D'Amico M, Sassoli C, Tani A, Cipriani G, Bogani C, Formigli L, Mazzanti R. “Mitochondrial expression and functional activity of breast cancer resistance protein in different multiple drug-resistant cell lines.” Cancer Res. 2009 Sep 15;69(18):7235-42.

10)A metal-supported biomimetic micromembrane allowing the recording of single-channel activity and of impedance spectra of membrane proteins. Bioelectrochemistry. 2010 Jun, 78(2):176-80.

11)Pillozzi S, Masselli M, De Lorenzo E, Accordi B, Cilia E, Crociani O, Amedei A, Veltroni M, D'Amico M, Basso G, Becchetti A, Campana D, Arcangeli A. Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers. Blood. 2011 Jan 20;117(3):902-14.

12)Polvani S, Calamante M, Foresta V, Ceni E, Mordini A, Quattrone A, D'Amico M, Luchinat C, Bertini I, Galli A. “Acycloguanosyl 5'-thymidyltriphosphate, a thymidine analogue prodrug activated by telomerase, reduces pancreatic tumor growth in mice”. Gastroenterology. 2011 Feb;140(2):709-720.e9.

13)Becucci L, D'Amico M, Cinotti S, Daniele S, Guidelli R. Tethered bilayer lipid micromembranes for single-channel recording: the role of adsorbed and partially fused lipid vesicles. Phys Chem Chem Phys. 2011 Aug 7;13(29):13341-8. 

14)D'Amico M, Gasparoli L, Arcangeli A. Potassium Channels: Novel Emerging Biomarkers and Targets for Therapy in Cancer. Recent Pat Anticancer Drug Discov. 2013 Jan 1;8(1):53-65

15)Marzi I, Cipolleschi MG, D'Amico M, Stivarou T, Rovida E, Vinci MC, Pandolfi S, Dello Sbarba P, Stecca B, OlivottoThe involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and  reprogramming. Cell Cycle. 2013 Jan 15;12(2):353-64.

16)Polvani S, Tarocchi M, Tempesti S, Mello T, Ceni E, Buccoliero F, D'Amico M, Boddi V, Farsi M, Nesi S, Nesi G, Milani S, Galli A. COUP-TFII in pancreatic adenocarcinoma: Clinical implication for patient survival and tumor progression. Int J Cancer. 2013 Oct 1. 

17)Di Gennaro P, Romoli MR, Gerlini G, D'Amico M, Brandani P, Pimpinelli N, Borgognoni L. IDO and CD83 expression in human epidermal Langerhans cells. J Dermatol Sci. 2013 Oct 29. 

18)Cipolleschi MG, Marzi I, Santini R, Fredducci D, Vinci MC, D'Amico M, Rovida E, Stivarou T, Torre E, Dello Sbarba P, Stecca B, Olivotto M. Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets. Cell Cycle. 2013 Nov 5;13(2) 

19)Crociani O, Zanieri F, Pillozzi S, Lastraioli E, Stefanini M, Fiore A, Fortunato A, D'Amico M, Masselli M, De Lorenzo E, Gasparoli L, Chiu M, Bussolati O, Becchetti A, Arcangeli A. hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer. Sci Rep. 2013 Nov 25;3:3308.

Serena Pillozzi

BSC, PhD and Researcher in Experimental and Clinical Oncology. During her experience in the Laboratory of Molecular Biology at the University of Cambridge she learned cloning techniques and methods to express and purify the protein domains producted in yeast. She is able to conduct analysis in vitro and in vivo in order to determine toxicological, pharmocokinetics and pharmacodynamics effects. She is a specialist in the production of preclinical models of xenograft (bone marrow, subcutaneous or orthotopic) and genetically modified animals.

In DI.V.A.L., she is involved in the preclinical evaluation of drugs.

 

***Peer reviewed publications*** 

 

1) Pillozzi S, Fortunato A, De Lorenzo E, Borrani E, Giachi M, Scarselli G, Arcangeli A, Noci I. Over-Expression of the LH Receptor Increases DistantMetastases in an Endometrial Cancer Mouse Model. Front Oncol. 2013 Nov 19;3:285.

2) Crociani O, Zanieri F, Pillozzi S, Lastraioli E, Stefanini M, Fiore A,Fortunato A, D'Amico M, Masselli M, De Lorenzo E, Gasparoli L, Chiu M, Bussolati O, Becchetti A, Arcangeli A. hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer. Sci Rep. 2013Nov 25;3:3308.

3) Pillozzi S, Becchetti A. Ion channels in hematopoietic and mesenchymal stem cells. Stem Cells Int. 2012;2012:217910. doi: 10.1155/2012/217910.

4) Masselli M, Laise P, Tonini G, Fanelli D, Pillozzi S, Cetica V, Da Ros M, Sardi I, Buccoliero AM, Aricò M, Genitori L, Becchetti A, Arcangeli A.Deregulation of ion channel and transporter encoding genes in pediatric gliomas. Front Oncol. 2012 May 30;2:53.

5) Arcangeli A, Pillozzi S, Becchetti A. Targeting ion channels in leukemias: a new challenge for treatment. Curr Med Chem. 2012;19(5):683-96.

6) Pillozzi S, Masselli M, De Lorenzo E, Accordi B, Cilia E, Crociani O, Amedei A, Veltroni M, D'Amico M, Basso G, Becchetti A, Campana D, Arcangeli A. Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers. Blood. 2011 Jan 20;117(3):902-14.

7) Fortunato P, Pillozzi S, Tamburini A, Pollazzi L, Franchi A, La Torre A, Arcangeli A. Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway. BMC Cancer. 2010 Sep 22;10:504. doi: 10.1186/1471-2407-10-504.

8) Becchetti A, Pillozzi S, Morini R, Nesti E, Arcangeli A. New insights into the regulation of ion channels by integrins. Int Rev Cell Mol Biol. 2010;279:135-90.

9) Pillozzi S, Arcangeli A. Physical and functional interaction between integrins and hERG1 channels in cancer cells. Adv Exp Med Biol. 2010;674:55-67.

10) Arcangeli A, Crociani O, Lastraioli E, Masi A, Pillozzi S, Becchetti A. Targeting ion channels in cancer: a novel frontier in antineoplastic therapy.Curr Med Chem. 2009;16(1):66-93.

11) Becchi C, Pillozzi S, Fabbri LP, Al Malyan M, Cacciapuoti C, Della Bella C, Nucera M, Masselli M, Boncinelli S, Arcangeli A, Amedei A. The increase of endothelial progenitor cells in the peripheral blood: a new parameter for detecting onset and severity of sepsis. Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):697-705.

12) Noci I, Pillozzi S, Lastraioli E, Dabizzi S, Giachi M, Borrani E, Wimalasena  J, Taddei GL, Scarselli G, Arcangeli A. hLH/hCG-receptor expression correlates with in vitro invasiveness in human primary endometrial cancer. Gynecol Oncol. 2008 Dec;111(3):496-501.

13) Guasti L, Crociani O, Redaelli E, Pillozzi S, Polvani S, Masselli M, Mello T,Galli A, Amedei A, Wymore RS, Wanke E, Arcangeli A. Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells. Mol Cell Biol. 2008 Aug;28(16):5043-60.

14) Accordi B, Pillozzi S, Dell'Orto MC, Cazzaniga G, Arcangeli A, Kronnie GT, Basso G. Hepatocyte growth factor receptor c-MET is associated with FAS and when  activated enhances drug-induced apoptosis in pediatric B acute lymphoblastic leukemia with TEL-AML1 translocation. J Biol Chem. 2007 Oct 5;282(40):29384-93.

15) Pillozzi S, Brizzi MF, Bernabei PA, Bartolozzi B, Caporale R, Basile V, Boddi V, Pegoraro L, Becchetti A, Arcangeli A. VEGFR-1 (FLT-1), beta1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome. Blood. 2007 Aug 15;110(4):1238-50.

16) Holmes O, Pillozzi S, Deakin JA, Carafoli F, Kemp L, Butler PJ, Lyon M, Gherardi E. Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains. J Mol Biol. 2007 Mar 23;367(2):395-408.

17) Cherubini A, Hofmann G, Pillozzi S, Guasti L, Crociani O, Cilia E, Di Stefano P, Degani S, Balzi M, Olivotto M, Wanke E, Becchetti A, Defilippi P, Wymore R, Arcangeli A. Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling. Mol Biol Cell. 2005 Jun;16(6):2972-83.

18) Arcangeli A, Becchetti A, Cherubini A, Crociani O, Defilippi P, Guasti L, Hofmann G, Pillozzi S, Olivotto M, Wanke E. Physical and functional interaction between integrins and hERG potassium channels. Biochem Soc Trans. 2004 Nov;32(Pt 5):826-7..

19) Polvani S, Masi A, Pillozzi S, Gragnani L, Crociani O, Olivotto M, Becchetti A, Wanke E, Arcangeli A. Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3. Gene Expr Patterns. 2003 Dec;3(6):767-76.

20) Cherubini A, Pillozzi S, Hofmann G, Crociani O, Guasti L, Lastraioli E, Polvani S, Masi A, Becchetti A, Wanke E, Olivotto M, Arcangeli A. HERG K+ channels and beta1 integrins interact through the assembly of a macromolecular complex. Ann N Y Acad Sci. 2002 Nov;973:559-61..

21) Pillozzi S, Brizzi MF, Balzi M, Crociani O, Cherubini A, Guasti L, Bartolozzi B, Becchetti A, Wanke E, Bernabei PA, Olivotto M, Pegoraro L, Arcangeli A. HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors. Leukemia. 2002 Sep;16(9):1791-8.

22) Hofmann G, Bernabei PA, Crociani O, Cherubini A, Guasti L, Pillozzi S, Lastraioli E, Polvani S, Bartolozzi B, Solazzo V, Gragnani L, Defilippi P, Rosati B, Wanke E, Olivotto M, Arcangeli A. HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation ofalpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1. J Biol Chem. 2001 Feb 16;276(7):4923-31.

23) Frangioni G, Borgioli G, Bianchi S, Pillozzi S. Relationships between hepaticmelanogenesis and respiratory conditions in the newt, Triturus carnifex. J Exp Zool. 2000 Jul 1;287(2):120-7. 

 

 

Laura Carraresi

BSC, Specialist in Biochemistry and Clinical Chemistry, PhD in Physiopathology and Cellular Pathology. From 2008 she works at Li.G.E.M.A. Dr. Carraresi is able to use the fundamental techniques of molecular biology to produce different animal models. In particular, she has an expertise in manipulating mouse stem cells and also in techniques involving mammalian genetic engineering - microinjection in mouse zygote pronucleus and gene targeting in mouse stem cells - to product genetically modified models.

 

 

***Peer reviewed publications*** 

 1)Filoni C, Caciotti A, Carraresi L, Cavicchi C, Parini R, Antuzzi D, Zampetti A, Feriozzi S, Poisetti P, Garman SC, Guerrini R, Zammarchi E, Donati MA, Morrone A. Functional studies of new GLA gene mutations leading to conformational Fabry disease. Biochim Biophys Acta. 2010 Feb;1802(2):247-52.

2)Filoni C, Caciotti A, Carraresi L, Donati MA, Mignani R, Parini R, Filocamo M, Soliani F, Simi L, Guerrini R, Zammarchi E, Morrone A. Unbalanced GLA mRNAs ratioquantified by real-time PCR in Fabry patients' fibroblasts results in Fabrydisease. Eur J Hum Genet. 2008 Nov;16(11):1311-7.

3)Carraresi L, Parini R, Filoni C, Caciotti A, Sersale G, Tomatsu S, Orlando C, Zammarchi E, Guerrini R, Donati MA, Morrone A. GALNS gene expression profiling in Morquio A patients' fibroblasts. Clin Chim Acta. 2008 Nov;397(1-2):72-6.

4)Carraresi L, Martinelli R, Vannoni A, Riccio M, Dembic M, Tripodi S, Cintorino M, Santi S, Bigliardi E, Carmellini M, Rossini M. Establishment and characterization of murine small cell lung carcinoma cell lines derived fromHPV-16 E6/E7 transgenic mice. Cancer Lett. 2006 Jan 8;231(1):65-73.

5)Buonomo T, Carraresi L, Rossini M, Martinelli R. Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins. J Transl Med. 2011 Jan 4;9:2.

6)Carraresi L, Tripodi SA, Mulder LC, Bertini S, Nuti S, Schuerfeld K, Cintorino M, Bensi G, Rossini M, Mora M. Thymic hyperplasia and lung carcinomas in a line of mice transgenic for keratin 5-driven HPV16 E6/E7 oncogenes. Oncogene. 2001 Dec 6;20(56):8148-53.

7)Mora M, Lazzer M, Marsicano G, Mulder LC, Carraresi L, Pieri A, Benanchi A, Grifoni D, Nuti S, Bruzzone P, Comporti M, Cortesini R, Rossini M. An in vivo model of hyperacute rejection: characterization and evaluation of the effect of transgenic human complement inhibitors. Transgenic Res. 2000 Jun;9(3):205-13.

8)Carraresi L, Mora M, Lazzeri M, Orsini E, Romagnoli R, Comporti M, Carli A, Carmellini M, Rossini M. Hepatocyte grafting as an alternative to liver transplant. Transplant Proc. 2001 Nov-Dec;33(7-8):3474-6.

9)Modesti A, Cirri P, Raugei G, Carraresi L, Magherini F, Manao G, Camici G, Ramponi G. Expression, purification and kinetic behaviour of fission yeast low M(r) protein-tyrosine phosphatase. FEBS Lett. 1995 Nov 20;375(3):235-8.

10)Modesti A, Bini L, Carraresi L, Magherini F, Liberatori S, Pallini V, Manao G, Pinna LA, Raugei G, Ramponi G. Expression of the small tyrosine phosphatase (Stp1) in Saccharomyces cerevisiae: a study on protein tyrosineElectrophoresis. 2001 Feb;22(3):576-85.

 

 

 

Marco Bizzicalupo
BSC anh PhD in Biology, Professor of Genetics since 2000.

His main scientific interests are in Microbial Molecular Genetics and Biotechnology applications of Genetics. The contribution of Prof. Bazzicalupo in DI.V.A.L. concerns in particular activities in the field of bacterial Genetics, Microbiology and Biotechnology.

 

Colorobbia

Colorobbia Consulting srl is a corporate of Gruppo Colorobbia specialised in technology services and development of new materials. Its business is pursued through four Divisions, closely integrated among each other, supporting the Group’s companies as well as the external market with a 360-degree service, capable of meeting any requirement in term of research, chemical and chemical-physical analysis, compliance with environmental and safety regulations in force, IT and process plant engineering.

Armando CasazzaGraduate in Aeronautical Engineering from the Politecnico di Milano in July 1980. He is highly competent in the creation of mathematical models of dynamic simulation; mechanical design calculations and radar; manufacturing engineering mechanics; project planning and management.

He is the CEO of the company. 

 

Graduate in Veterinary Medicine, PhD in Biology of Human Reproduction and Animal; she researched and published on topics related to Biotechnology applied to animal reproduction.

She is currently Veterinary Manager at the Asl 4 in Prato, where she is also the representative for the management of the Quality System.