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The research in nano-medicine represents the most innovative activity of the proposed solutions.

Our goals are:

  • develop targeted theranostic systems for diagnostic and therapeutic purposes;

  • develop new delivery systems for pharmaceuticals out of patent or drugs affected by systemic toxicity, with the aim to reduce the public health spending.

DI.V.A.L. conducts biotechnological studies on nano-antibodies and nano-particles.

Nanomaterial’ means a natural, incidental or manufactured material containing particles, in an unbound state or as an aggregate or as an agglomerate and where, for 50% or more of the particles in the number size distribution, one or more external dimensions is in the size range 1-100 nm.» (Commission Recommendation 2011/696/EU on the definition of nanomaterial).

Since nanoparticles exhibit specific characteristics that differ from the characteristics of larger sized particles with the same chemical composition, further clarification is needed in the risk assessment of such products.  The nano-related risk of nanomaterials is mainly associated with the possibility of the release of free nanoparticles from the particulate substance, and their potential toxic effects. For this purpose, a detailed characterisation and identification of the nanomaterial is essential. 

DI.V.A.L. can perform toxicokinetic and toxicological evaluation of nanomaterials. Some of the toxicological analysis we can provide:

  • Cytotoxicity (ISO 10993 – 5:2009)
  • Acute toxicity (ISO 10993-11: 2006)
  • Irritation activity (ISO – 10993-10:2010)
  • Delayed-type hypersensitivity (ISO – 10993-10:2010)
  • Genotoxicity (ISO 10993-1)
  • Repeated- dose toxicity (ISO 10993-11:2006)
  • Implantation (ISO 19003-6:2007)
  • Chronic toxicity/carcinogenicity (ISO 10993–3:2003)

DI.V.A.L therefore offers:

  • nano-particles and nano-antibodies;

  • antibodies functionalized nano-particles;

  • nano-toxicological tests