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Services for drug screening
Analysis of Small Molecules and Nano-formulations

   1. TOXICOLOGY
In vitro
       a) GENETIC TOXICOLOGY
  • Bacterial Mutation Assay - Ames Test (Standard Method)

b) CYTOGENETICS AND GENOME RESEARCH

  • Karyotype test
  • Gene Expression Profile (Micro-array Assay)

c) CYTOTOXICITY

In vivo

  • Acute Oral Toxicity Study*
  • Acute Dermal Toxicity Study in Rabbit
  • Single Dose and Dose range Finding Study*
  • Repeated Dose Toxicity Study (up to 52 weeks)*

* Studies in mice, rats and guinea pigs

2. CARDIAC SAFETY
In vitro
  • hERG KV11.1 Test (ICH S7B)
- Manual Patch Clamp
- Automated Patch Clamp
  •       hERG1A/1B Test 
  •       CARDIAC SAFETY PROFILE (hERG, Nav1.5, Cav1.2, KvLQT1, Kir2.1)

Ex vivo


CARDIAC ACTION POTENTIAL (cAP) on isolated guinea pig cardiomyocytes

In vivo


QT MEASUREMENT on anesthetized guinea pigs

3. PHARMACOKINETICS

4. PHARMACODYNAMICS: Anti-tumoral activity evaluation

We generate in vivo models for the assessment of anticancer activity.
We are able to conduct animal monitoring by bioimaging technique.

5. HIGH-THROUGHPUT ION CHANNEL SCREENING