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Ion channel assays are essential in Drug Discovery for identifying promising new clinical compounds, but also for minimizing the probability of potential side effects.
 
Many drugs aimed to ion channels were discovered using binding or cellular alternative technologies based either on ion fluxes that on voltage sensitive fluorescent dyes. However, these methods lack the precision, temporal resolution, and voltage control that is necessary for characterizing important pharmacological features of drug–channel interactions. In particular, they do not capture several major characteristics of ion channel function: voltage dependence, use dependence, or fast voltage transients that render them unsuitable to study kinetic properties.
 
Our expertise allow us to study possible changes drug/compound induced either on the electrophysiological properties of the HERG channel (i.e. kinetics of activation/inactivation gating) either on the intracellular signalling through the functional interplay between the integrins and hERG1.