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Preclinical Services

Preclinical in-vitro and in-vivo services for screening and evaluation of new drugs and formulations

We adopt an integrated approach for the safety pharmacology assessment of cancer diseases, ranging from in vitro cell culture assays to in vivo models.

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We provide a wide range of services, fully customizable, following our customer needs. ​

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in vitro Services

in vitro toxicology                        

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Molecular biology

Immunology

Biochemistry

Analytical chemistry

Genetic toxicology

Safety pharmacology

Cardiac safety

  • hERG KV11.1 Test (ICH S7B)

    • Manual Patch Clamp

    • Automated Patch Clamp

  • hERG 1A/1B Test 

  • Cardiac Safety Profile (hERG, Nav1.5, KvLQT1, Kir2.1)

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in vitro Toxicology

  • WST-1 Assay

  • Trypan Blue Exclusion Test

  • Apoptosis Annexin V-PI Flow Cytometry Assay

  • Apoptosis Tunel Assay

  • Agar diffusion test

  • Biomarkers

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Immunology

  • ELISA assays

  • Isolation and cell characterization

  • Cytokine and receptor analysis

  • Western blot

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Molecular biology

  • PCR

  • DNA/RNA isolation, profiling and sequencing

  • Invasiveness

  • Real Time PCR

  • Gene expression

  • Biomarker discovery

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Genotoxicity

  • Bacterial Reverse Mutation (Ames) Study (according to OECD 471 Guidelines)

  • Bacterial Reverse Mutation (Ames) Study (ASTM E1687-04)

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Biochemistry

  • Enzyme assay and immunochemistry

  • Drug potency/concentration

  • Protein production, purification and analysis

  • Immunohistochemistry

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Cellular assay services

  • Soft Agar Colony formation Assay

  • Migration

  • Invasiveness

  • Cell Signaling Evaluation

  • Custom-Tailored Cellular Assay Services

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Drug delivery

  • Transcytosis

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in vivo Services

Pharmacokinetic​

Bioavailability

Toxicology

Oncological models

Disease models

Custom animal models

in vivo laboratory support

  • Analytical chemistry

  • Clinical pathology

  • Histopathology

  • Surgical research

  • Microbiology

  • Micro-surgery 

  • Necropsy

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Animal models

  • Xenograft tumor models (orthotropic, intravenous, subcutaneous)

  • Bone marrow tumor models

  • Metastatic tumor models

  • Syngenetic models

  • Lung and respiratory disease models

  • Ophthalmology research models

  • Cardiovascular disease models

  • Nutrition related disease models

  • Neurological models

  • Psoriasis models

  • Gastrointestinal diseases models

  • Metabolic disease models

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Toxicology

  • Acute systemic toxicity

  • Subacute/subcronic/chronic toxicity

  • Toxicokinetics/metabolism

  • ADME

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Custom models services

  • Production of innovative mouse models

  • Customization of pre existing models

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Ion channels

Manual patch clamp

Automated patch clamp

Cardiac Safety/hERG test

Oncological models-custom tailored cells

If you need more information about our customizable services...

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