Preclinical Services
Preclinical in-vitro and in-vivo services for screening and evaluation of new drugs and formulations
in vitro Services
in vitro toxicology
Molecular biology
Immunology
Biochemistry
Analytical chemistry
Genetic toxicology
Safety pharmacology
Cardiac safety
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hERG KV11.1 Test (ICH S7B)
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Manual Patch Clamp
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Automated Patch Clamp
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hERG 1A/1B Test
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Cardiac Safety Profile (hERG, Nav1.5, KvLQT1, Kir2.1)
in vitro Toxicology
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WST-1 Assay
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Trypan Blue Exclusion Test
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Apoptosis Annexin V-PI Flow Cytometry Assay
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Apoptosis Tunel Assay
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Agar diffusion test
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Biomarkers
Immunology
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ELISA assays
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Isolation and cell characterization
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Cytokine and receptor analysis
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Western blot
Molecular biology
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PCR
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DNA/RNA isolation, profiling and sequencing
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Invasiveness
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Real Time PCR
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Gene expression
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Biomarker discovery
Genotoxicity
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Bacterial Reverse Mutation (Ames) Study (according to OECD 471 Guidelines)
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Bacterial Reverse Mutation (Ames) Study (ASTM E1687-04)
Biochemistry
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Enzyme assay and immunochemistry
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Drug potency/concentration
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Protein production, purification and analysis
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Immunohistochemistry
Cellular assay services
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Soft Agar Colony formation Assay
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Migration
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Invasiveness
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Cell Signaling Evaluation
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Custom-Tailored Cellular Assay Services
Drug delivery
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Transcytosis
in vivo Services
Pharmacokinetic
Bioavailability
Toxicology
Oncological models
Disease models
Custom animal models
in vivo laboratory support
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Analytical chemistry
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Clinical pathology
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Histopathology
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Surgical research
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Microbiology
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Micro-surgery
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Necropsy
Animal models
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Xenograft tumor models (orthotropic, intravenous, subcutaneous)
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Bone marrow tumor models
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Metastatic tumor models
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Syngenetic models
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Lung and respiratory disease models
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Ophthalmology research models
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Cardiovascular disease models
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Nutrition related disease models
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Neurological models
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Psoriasis models
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Gastrointestinal diseases models
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Metabolic disease models
Toxicology
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Acute systemic toxicity
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Subacute/subcronic/chronic toxicity
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Toxicokinetics/metabolism
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ADME
Custom models services
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Production of innovative mouse models
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Customization of pre existing models